We are at 6 U2 and this issue has plagued us since the first migration to v6. We have a external PSC for all vCenters and a total of 4 vCenters connected. Around every 3 days the issue occurs when you login to the client. If you stay logged in and never refresh your page it works but if you logout and back in it occurs. We have fixed the issue temporarliy by rebooting the PSC's and the vCenters and it begins to work. I will paste screenshots so you can see the results.
We can see tasks for all vCenters but buttons do nothing and clicking a VM does not take you there. C# client works fine